![]() A controlled study of the activity of hyaluronic acid in the treatment of venous leg ulcers. Interactions of hyaluronicacid with the skin and implications for the dermal delivery of biomacromolecules.DOI: Hyaluronic acid derivatives and their healing effect on burns,epithelial surgical wounds, and chronic wounds: A systematic review andmeta-analysis of randomized controlled trials. The tricky tear trough: A review of topical cosmeceuticalsfor periorbital skin rejuvenation. Efficacy ofcream-based novel formulations of hyaluronic acid of different molecularweights in anti-wrinkle treatment. (2012).Hyaluronic acid: A key molecule in skin aging. Double-blind,randomized clinical study comparing hyaluronic acid cream to placebo inpatients treated with radiotherapy. Topical treatment of partial thickness burns by silversulfadiazine plus hyaluronic acid compared to silver sulfadiazine alone: adouble-blind, clinical study. Efficacy of a newtopical nano-hyaluronic acid in humans. Active ingredients: Squalane and avocado oil. Best for: Post-chemical peel, sunburns, and general dryness. ![]() Second-degreeburns: A comparative, multicenter, randomized trial of hyaluronic acid plussilver sulfadiazine vs. Ahead, read my honest review of Biafine Emulsion Cream. Hyaluronic acidimpedes reepithelialization of skin graft donor sites. You can learn more about how we ensure our content is accurate and current by reading our editorial policy. Healthline has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical associations. Larger molecules, with a molecular weight greater than 500 kDa, had a more difficult time passing through the skin barrier. A recent study investigated the efficacy of a topical, low molecular nano-hyaluroid acid, and found that smaller substances under 500 kDa: The diameter of hyaluronic acid is also important as it too determines the ingredient’s ability to penetrate the skin. You can read more about this molecular weight analysis from the original breakdown here. All the other molecular weights still improved elasticity and skin hydration, just less so. Both the 50 and 130 kDa groups had significant improvement in wrinkle-depth and skin roughness after 60 days. How did we get this number? When you look at studies, you’ll see a pattern, but one of the most thorough studies looked at HA with different molecular weights, including 50, 130, 300, 800, and 2,000 kDa.Īfter one month, they found that treatment with 130 kDa HA was the most effective, increasing skin elasticity by 20 percent. Anything higher won’t make too much of a difference. HA between 50 to 1,000 kDa is the most beneficial for skin, with about 130 kDa being the best, according to the most recent human studies. This is measured in something called unified atomic mass units - daltons, or kDa for short. In this case, size matters! The molecular weight refers to its mass, or how big the HA molecule is. The benefits of hyaluronic acid on the skin has to do with its molecular weight and concentration. What’s the science behind hyaluronic acid?
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